The growing urgency of transformative, mission-oriented policymaking brings forth a host of extensive requirements that pose challenges to the existing structures and practices of public officials. In many cases, established institutional settings, organizational routines and administrative cultures fall short of meeting the rigorous requirements associated with the evolving paradigm of mission-orientation. The case of Germany, where various structural factors undermine the effectiveness of transformative policymaking, serves as a vivid and compelling illustration of these issues. The authors of this paper advocate for the creation of a specialized mission agency to effectively tackle the demanding governance requirements of transformative, mission-oriented policies in Germany. This agency, equipped with expertise in specific thematic areas, should possess the autonomy to operate within the scope of its competencies and assume a prominent role in the design and governance of individual missions that fall under the purview of the Federal Chancellery.